Dimethylformamide → (5,6-Dihydro-benzo[h]quinazolin-2-yl)-phenyl-amine

HRID 643762Notes

Reaction equation

HRID 643762 reaction equation
C[N:2]([CH:4]=[C:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]1=O)[CH3:3].[C:16]1([NH:22]C(N)=N)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C[N:27](C=O)C>>[N:27]1[C:6]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH2:13][CH2:14][C:5]=2[CH:4]=[N:2][C:3]=1[NH:22][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 544065092-dimethylaminomethylene-3,4-dihydro-2H-naphthalen-1-oneHCID 178418923HCID 178418923, compound

Product 1

HCID 67406319(5,6-Dihydro-benzo[h]quinazolin-2-yl)-phenyl-amine

Procedure

A solution of 2-dimethylaminomethylene-3,4-dihydro-2H-naphthalen-1-one 100 mg in 5 ml DMF and 3 eq. of N-phenyl-guanidine was stirred at 110° C. for overnight, the product was purified by directly injecting the DMF reaction solution into prep HPLC.

Workup

  1. customthe product was purified
  2. customthe DMF reaction solution into prep HPLC

Sources & evidence

ORD record
ord-7d97d143fd4b4cb3bf0038a75ca7a530
Source dataset
uspto-grants-2010_04
Patent number
US07700609B2

Reaction notes

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