2-Chloro-4-Phenylphenol → 5-(3-Chloro-biphenyl-4-yloxymethyl)-furan-2-carboxylic acid

HRID 643788Notes

Reaction equation

HRID 643788 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[OH:14].C[O:16][C:17]([C:19]1[O:20][C:21]([CH2:24]Cl)=[CH:22][CH:23]=1)=[O:18]>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[O:14][CH2:24][C:21]1[O:20][C:19]([C:17]([OH:18])=[O:16])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 70742-Chloro-4-PhenylphenolHCID 75065Methyl 5-(chloromethyl)-2-furoate

Product 1

HCID 112211655-(3-Chloro-biphenyl-4-yloxymethyl)-furan-2-carboxylic acid

Procedure

5-(3-Chloro-biphenyl-4-yloxymethyl)-furan-2-carboxylic acid was prepared using general procedure A from 2-chloro-4-phenylphenol (available from TCI America, Portland, Oreg.) and 5-chloromethylfuran-2-carboxylic acid methyl ester (available from Aldrich, Milwaukee, Wis., or from Maybridge plc, Tintagel, UK). Yield: 66 mg. Mass spectrum (ES) MH+=329.

Sources & evidence

ORD record
ord-12f4a147e2ac42bd99d7f4543aac34a9
Source dataset
uspto-grants-2010_04
Patent number
US07700632B2

Reaction notes

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