HRID643834

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：C=C[C@@H]1C[C@]1(NC(=O)C1CC(Oc2cc(-c3ccccc3)nc3cc(OC)ccc23)C=C1C(=O)OC)C(=O)OC(C)(C)C

HCID59204187

未命名化合物

PRODUCTS

生成物

结构：C=C[C@@H]1C[C@]1(NC(=O)C1CC(Oc2cc(-c3ccccc3)nc3cc(OC)ccc23)C=C1C(=O)O)C(=O)OC(C)(C)C

HCID59391614

未命名化合物

收率 90%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21886435

1,4-Dioxane--water (1/1)

C4H10O3

PROCEDURE

实验过程

The methyl ester 30 (35 mg, 59 mmol) was dissolved in dioxane/water (1:1, 4 mL) and LiOH (1.2 mmol) was added. The reaction was stirred over night and then co-concentrated. This gave the title compound (0.32 g, 90%) as a yellow salt.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-72844b94f03d48b6ad5bac44c533e718
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07700552B2
来源说明: uspto-grants-2010_04

反应 SMILES

C[O:2][C:3]([C:5]1[CH:9]([C:10](=[O:24])[NH:11][C@:12]2([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:14][C@H:13]2[CH:15]=[CH2:16])[CH2:8][CH:7]([O:25][C:26]2[C:35]3[C:30](=[CH:31][C:32]([O:36][CH3:37])=[CH:33][CH:34]=3)[N:29]=[C:28]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH:27]=2)[CH:6]=1)=[O:4].[Li+].[OH-]>O1CCOCC1.O>[C:20]([O:19][C:17]([C@@:12]1([NH:11][C:10]([CH:9]2[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]([O:25][C:26]3[C:35]4[C:30](=[CH:31][C:32]([O:36][CH3:37])=[CH:33][CH:34]=4)[N:29]=[C:28]([C:38]4[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=4)[CH:27]=3)[CH2:8]2)=[O:24])[CH2:14][C@H:13]1[CH:15]=[CH2:16])=[O:18])([CH3:21])([CH3:22])[CH3:23]