Bromopyruvic Acid → HCID 22250270, compound

HRID 643854Notes

Reaction equation

HRID 643854 reaction equation
Br[CH2:2][C:3](=O)[C:4]([OH:6])=[O:5].[CH3:8][N:9]([CH3:13])[C:10]([NH2:12])=[S:11]>C1COCC1>[CH3:8][N:9]([CH3:13])[C:10]1[S:11][CH:2]=[C:3]([C:4]([OH:6])=[O:5])[N:12]=1

Participants

4

Reactant 2

HCID 70684Bromopyruvic AcidHCID 30341921,1-Dimethyl-2-thiourea

Product 1

HCID 22250270HCID 22250270, compoundYield 87.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Bromopyruvic acid (2.94 g, 17.6 mmol) was added to a stirred solution of 1,1-dimethyl-thiourea (1.87 g, 17.6 mmol) in dry THF (60 mL). The reaction mixture was stirred at rt for 4 hrs. The precipitate that had formed was filtered off, washed with cold THF and dried on high vacuum. LC-MS showed the product peak. The product was obtained as a white solid (2.64 g, 59%).

Workup

  1. customThe precipitate that had formed
  2. filtrationwas filtered off
  3. washwashed with cold THF
  4. customdried on high vacuum

Sources & evidence

ORD record
ord-64f980ca668b44f090611714210db710
Source dataset
uspto-grants-2010_04
Patent number
US07700552B2

Reaction notes

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