反应详情

温度

70 °C

To a suspension of 3,7-bis-benzyloxynaphthalene-2-carboxylic acid benzyl ester (4.0 g, 8.4 mmol) in EtOH (75 mL), is added 10 mL of 1.0N NaOH (1.2 eq.) and the mixture is stirred at 70° C. for 18 h. The solvent is removed under reduced pressure and the residual solid is dissolved in 250 mL of water. The solution is washed with EtOH and the aqueous phase is acidified with 2N HCl. The resulting precipitate is filtered, washed with water and dried to afford 3,7-bis-benzyloxynaphthalene-2-carboxylic acid as a pale-yellow solid: mp=163-165° C.; (M−H)−=383.

1. customThe solvent is removed under reduced pressure
2. dissolutionthe residual solid is dissolved in 250 mL of water
3. washThe solution is washed with EtOH
4. filtrationThe resulting precipitate is filtered
5. washwashed with water
6. customdried