Sodium Hydroxide → HCID 66750570, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 3,7-bis-benzyloxynaphthalene-2-carboxylic acid benzyl ester (4.0 g, 8.4 mmol) in EtOH (75 mL), is added 10 mL of 1.0N NaOH (1.2 eq.) and the mixture is stirred at 70° C. for 18 h. The solvent is removed under reduced pressure and the residual solid is dissolved in 250 mL of water. The solution is washed with EtOH and the aqueous phase is acidified with 2N HCl. The resulting precipitate is filtered, washed with water and dried to afford 3,7-bis-benzyloxynaphthalene-2-carboxylic acid as a pale-yellow solid: mp=163-165° C.; (M−H)−=383.

Provenance & Evidence