HCID 66750641, compound → HCID 59263256, compound

HRID 643892Notes

Reaction equation

HRID 643892 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[CH:5]([CH3:28])[CH2:6][CH2:7][CH2:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][C:13]([N:20]3[CH2:24][C:23](=[O:25])[NH:22][S:21]3(=[O:27])=[O:26])=[C:14]([OH:19])[CH:15]=2)[CH:10]=1)C>CO>[CH3:1][O:3][C:4](=[O:29])[CH:5]([CH3:28])[CH2:6][CH2:7][CH2:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][C:13]([N:20]3[CH2:24][C:23](=[O:25])[NH:22][S:21]3(=[O:26])=[O:27])=[C:14]([OH:19])[CH:15]=2)[CH:10]=1

Participants

3

Reactant 1

HCID 66750641HCID 66750641, compound

Product 1

HCID 59263256HCID 59263256, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound is prepared analogously to Example 32, step B, starting from 5-[6-hydroxy-7-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-naphthalen-2-yl]-2-methylpentanoic acid ethyl ester (Example 9-4) and the reaction is performed in solvent MeOH instead of i-PrOH: Retention time=1.17 min (Method A); (M−H)−=405.

Sources & evidence

ORD record
ord-fc2b922691194798867b7060ad2fd12e
Source dataset
uspto-grants-2010_04
Patent number
US07700633B2

Reaction notes

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