Hydrochloric Acid → HCID 57238489, compound

HRID 643915Notes

Reaction equation

HRID 643915 reaction equation
[CH2:1]([CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:13][CH3:14])[CH:9]=2)[C:4]1=O)[CH3:2].[BH4-].[Na+].Cl>CO>[CH2:1]([C:3]1[CH2:12][CH2:11][C:10]2[C:5]([CH:4]=1)=[CH:6][CH:7]=[C:8]([O:13][CH3:14])[CH:9]=2)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 14214131HCID 14214131, compound

Product 1

HCID 57238489HCID 57238489, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-ethyl-6-methoxy-3,4-dihydro-2H-naphthalen-1-one (6.10 g, 29.9 mmol) in MeOH (70 mL) at 0° C. is added NaBH4 slowly and the mixture is stirred at RT for 30 min. Then 2M HCl solution (200 mL) is added and the mixture is stirred for 10 min before it is extracted with EtOAc and concentrated. The residue is purified to give the title compound as a clear oil: (M+H)+=189.

Workup

  1. stirringthe mixture is stirred for 10 min before it
  2. extractionis extracted with EtOAc
  3. concentrationconcentrated
  4. customThe residue is purified

Sources & evidence

ORD record
ord-e9e1098207624b48a1604194ac355c33
Source dataset
uspto-grants-2010_04
Patent number
US07700633B2

Reaction notes

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