Potassium Hydroxide → HCID 66750538, compound

HRID 643944Notes

Reaction equation

HRID 643944 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[C:10]([N:23]1[CH2:27][C:26](=[O:28])[NH:25][S:24]1(=[O:30])=[O:29])[CH:9]=2)=[O:5])C.[OH-].[K+]>O>[CH2:16]([O:15][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][C:10]=1[N:23]1[CH2:27][C:26](=[O:28])[NH:25][S:24]1(=[O:30])=[O:29])[NH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:14]2)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 66750840HCID 66750840, compound

Product 1

HCID 66750538HCID 66750538, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 5-benzyloxy-6-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-1H-indole-2-carboxylic acid ethyl ester (from Example 65) (0.135 g, 0.398 mmol) in water (8 mL) is added 1M KOH (0.29 mL). The solution is stirred at room temperature for 1 h. The reaction product is lyophilized to yield 5-benzyloxy-6-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-1H-indole-2-carboxylic acid.

Sources & evidence

ORD record
ord-0e0fc1b747d449e8ae85d5033d037a41
Source dataset
uspto-grants-2010_04
Patent number
US07700633B2

Reaction notes

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