AURORA 623 → HCID 43576350, compound

HRID 644001Notes

Reaction equation

HRID 644001 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][S:11]([C:14]1[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=1)(=[O:13])=[O:12].[H][H]>C(O)C.[Pd]>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][S:11]([C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1)(=[O:12])=[O:13]

Participants

5

Reactant 2

HCID 721284AURORA 623HCID 178418361HCID 178418361, compound

Product 1

HCID 43576350HCID 43576350, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of the title A compound, 2-(4-nitro-benzenesulfonylamino)-benzoic acid methyl ester (1 g, 2.98 mmol) in 40 mL of ethanol containing 0.32 g of 10% palladium on carbon is shaken under 40 psi of hydrogen pressure at RT for 2.5 h. The mixture is filtered and concentrated under vacuum to give 2-(4-amino-benzenesulfonyl-amino)-benzoic acid methyl ester.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-e7b4f166e48b48f797023784d272dfc6
Source dataset
uspto-grants-2010_04
Patent number
US07700637B2

Reaction notes

Loading…