反应详情

温度

0 °C

Lithium aluminum hydride (61 mL of a 1.0 M solution in THF) is added to a solution of the title A compound, 5-methyl-2-phenyl-4-(2-p-tolyloxy-ethyl)-oxazole (8.22 g, 24.36 mmol) in THF (200 mL) at 0° C. The mixture is stirred at 0° C. for 5 h, then at RT overnight. The reaction mixture is then cooled in an ice-water bath and quenched with saturated aqueous sodium bicarbonate and concentrated under vacuum to remove some of the THF. The residue is extracted with EtOAc, and the resulting organic phase is washed with brine, dried with magnesium sulfate, and concentrated under vacuum to give {4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-methanol as a white solid.

1. customat RT
2. customovernight
3. temperatureThe reaction mixture is then cooled in an ice-water bath
4. customquenched with saturated aqueous sodium bicarbonate
5. concentrationconcentrated under vacuum
6. customto remove some of the THF
7. extractionThe residue is extracted with EtOAc
8. washthe resulting organic phase is washed with brine
9. dry with materialdried with magnesium sulfate
10. concentrationconcentrated under vacuum