反应详情

Triphenylphosphine (2.54 g, 9.7 mmol) is added to a solution of carbon tetrabromide (3.22 g, 9.7 mmol) and the title B compound, {4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-methanol (2.0 g, 6.46 mmol) in DCM (24 mL) at RT. The mixture is stirred overnight and then concentrated under vacuum. The residue is chromatographed on silica gel using 15% EtOAc in hexane as the eluent to provide 4-[2-(4-bromomethyl-phenoxy)-ethyl]-5-methyl-2-phenyl-oxazole as a white solid.

1. customat RT
2. concentrationconcentrated under vacuum
3. customThe residue is chromatographed on silica gel using 15% EtOAc in hexane as the eluent