T-2307 free base → HCID 67370195, compound

HRID 644135Notes

Reaction equation

HRID 644135 reaction equation
[NH2:1][C:2](=[NH:32])[C:3]1[CH:31]=[CH:30][C:6]([O:7][CH2:8][CH2:9][CH2:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][O:20][C:21]3[CH:29]=[CH:28][C:24]([C:25]([NH2:27])=[NH:26])=[CH:23][CH:22]=3)[CH2:13][CH2:12]2)=[CH:5][CH:4]=1.[ClH:33].C(O)C>C(O)C>[ClH:33].[NH2:32][C:2](=[NH:1])[C:3]1[CH:31]=[CH:30][C:6]([O:7][CH2:8][CH2:9][CH2:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][O:20][C:21]3[CH:22]=[CH:23][C:24]([C:25]([NH2:27])=[NH:26])=[CH:28][CH:29]=3)[CH2:13][CH2:12]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 9803135T-2307 free baseHCID 21887872Ethanol hydrochloride

Product 1

HCID 67370195HCID 67370195, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To an ethanol (10 mL) suspension of 0.50 g of 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine was added 1.77 mL of a 2.6 mol/mL hydrogen chloride/ethanol solution at room temperature, which was then stirred at room temperature for 4 hours and 15 minutes. The precipitate was collected by filtration to provide 0.49 g of 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine hydrochloride as colorless solid form.

Workup

  1. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-f94070b000b34db4a2de169a66d451e1
Source dataset
uspto-grants-2010_04
Patent number
US07700623B2

Reaction notes

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