Hydrochloric Acid → HCID 68427067, compound

HRID 644156Notes

Reaction equation

HRID 644156 reaction equation
[ClH:1].[C:2]([CH2:5][CH2:6][CH2:7][CH2:8][N:9]([CH2:33][C:34]1[CH:42]=[CH:41][C:37]([C:38]([OH:40])=[O:39])=[CH:36][CH:35]=1)[CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=1[O:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1)([OH:4])=[O:3]>O1CCOCC1>[ClH:1].[C:2]([CH2:5][CH2:6][CH2:7][CH2:8][N:9]([CH2:33][C:34]1[CH:42]=[CH:41][C:37]([C:38]([OH:40])=[O:39])=[CH:36][CH:35]=1)[CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=1[O:19][CH2:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1)([OH:4])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10281200HCID 10281200, compound

Product 1

HCID 68427067HCID 68427067, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.5 ml (2 mmol) of a 4-molar solution of HCl in dioxane is added to a solution of 220 mg (0.43 mmol) of 4-{[(4-carboxybutyl)(2-{2-[(4-cyclohexylbenzyl)oxy]-4-fluorophenyl}ethyl)amino]methyl}benzoic acid from Ex. 1 in 0.2 ml of dioxane, and the mixture is stirred at 60° C. for 1 h. The mixture is then concentrated by evaporation and the resulting colorless oil is triturated repeatedly with diethyl ether. The resulting crystals are filtered and dried.

Workup

  1. concentrationThe mixture is then concentrated by evaporation
  2. customthe resulting colorless oil is triturated repeatedly with diethyl ether
  3. filtrationThe resulting crystals are filtered
  4. customdried

Sources & evidence

ORD record
ord-4a354ec23aca4d488faab5aa5fdeba88
Source dataset
uspto-grants-2010_04
Patent number
US07700653B2

Reaction notes

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