HRID644177

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID23293

3-Piperidinol

C5H11NO

结构：CC(C)(C)OC(=O)N1CCC(Oc2cc(F)ccc2C(=O)Nc2ccccc2C(=O)Nc2ccc(Cl)cn2)CC1

HCID68530207

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(Oc2cc(N3CCCC(O)C3)ccc2C(=O)Nc2ccccc2C(=O)Nc2ccc(Cl)cn2)CC1

HCID68532550

未命名化合物

收率 34%

PROCEDURE

实验过程

Using methods substantially equivalent to those described in Example 4-F, except that the reaction was quenched with water and the resulting precipitate was collected, 2-[2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(3-hydroxypiperidin-1-yl)-benzoylamino]-N-(5-chloropyridin-2-yl)-benzamide (166 mg, 0.26 mmol, 34%) was prepared from 2-[4-fluoro-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide and 3-hydroxypiperidine.

WORKUP

后处理

customwas quenched with water
customthe resulting precipitate was collected

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e68b6706cfe54f6283b7af0227cb4111
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07700628B2
来源说明: uspto-grants-2010_04

反应 SMILES

F[C:2]1[CH:26]=[CH:25][C:5]([C:6]([NH:8][C:9]2[CH:24]=[CH:23][CH:22]=[CH:21][C:10]=2[C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][N:15]=2)=[O:12])=[O:7])=[C:4]([O:27][CH:28]2[CH2:33][CH2:32][N:31]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:30][CH2:29]2)[CH:3]=1.[OH:41][CH:42]1[CH2:47][CH2:46][CH2:45][NH:44][CH2:43]1>>[C:37]([O:36][C:34]([N:31]1[CH2:30][CH2:29][CH:28]([O:27][C:4]2[CH:3]=[C:2]([N:44]3[CH2:45][CH2:46][CH2:47][CH:42]([OH:41])[CH2:43]3)[CH:26]=[CH:25][C:5]=2[C:6]([NH:8][C:9]2[CH:24]=[CH:23][CH:22]=[CH:21][C:10]=2[C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][N:15]=2)=[O:12])=[O:7])[CH2:33][CH2:32]1)=[O:35])([CH3:40])([CH3:39])[CH3:38]