2-amino-4-chloro-N-(5-chloropyridin-2-yl)benzamide → 2-[2-(2-tert-Butoxycarbonylaminoethoxy)-4-(morpholin-4-yl)-benzoylamino]-4-chloro-N-(5-chloropyridin-2-yl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	2-amino-4-chloro-N-(5-chloropyridin-2-yl)benzamide	HCID 21906199	—
Reactant	2-(2-Tert-butoxycarbonylaminoethoxy)-4-(morpholin-4-yl)benzoic acid	HCID 57602444	—
Product	2-[2-(2-tert-Butoxycarbonylaminoethoxy)-4-(morpholin-4-yl)-benzoylamino]-4-chloro-N-(5-chloropyridin-2-yl)benzamide	HCID 57860792	74%

Reaction Steps

Using methods substantially equivalent to those described in Example 29-G, 2-[2-(2-tert-butoxycarbonylaminoethoxy)-4-(morpholin-4-yl)benzoylamin]-4-chloro-N-(5-chloropyridin-2-yl)benzamide was prepared in a 74% yield from 2-amino-4-chloro-N-(5-chloropyridin-2-yl)benzamide and 2-(2-tert-butoxycarbonylaminoethoxy)-4-(morpholin-4-yl)benzoic acid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07700628B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-fee27ccc1b574016bc4def88a2c1425d
Source note	uspto-grants-2010_04