反应详情

温度

80 °C

The methyl 2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-fluorobenzoate (7.99 mmol, 22.6 mmol) was diluted with pyrrolidine (18 mL, 215.6 mmol). The resulting mixture was heated to 80° C. After 3 hours, the reaction was cooled to room temperature and quenched with water (50 mL). The mixture was extracted with dichloromethane (200 mL). The organic layer was washed with saturated aqueous citric acid (3×50 mL), dried over sodium sulfate, filtered, and concentrated to a colorless oil (9.14 g, 22.6 mmol, 100%).

1. temperaturethe reaction was cooled to room temperature
2. customquenched with water (50 mL)
3. extractionThe mixture was extracted with dichloromethane (200 mL)
4. washThe organic layer was washed with saturated aqueous citric acid (3×50 mL)
5. dry with materialdried over sodium sulfate
6. filtrationfiltered