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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 644221Generated: October 29, 2026

Methyl 4-fluorosalicylate → Methyl 4-fluoro-2-(3-tert-butoxycarbonylaminopropoxy)benzoate

https://huagongshe.com/reaction/644221

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-fluorosalicylateHCID 2775386—
Reactanttert-butyl N-(3-hydroxypropyl)carbamateHCID 3838134—
ProductMethyl 4-fluoro-2-(3-tert-butoxycarbonylaminopropoxy)benzoateHCID 5760245384%

Reaction Steps

Using a procedure analogous to Example 1-C, methyl 2-hydroxy-4-fluorobenzoate and 3-(tert-butoxycarbonylamino)propanol gave the desired product as a white solid (20.6 g, 84%). 1NMR IS-MS, m/e: 328 (m+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07700628B2
Source datasetuspto-grants-2010_04
ORD IDord-7703097fe671402eb56334e383416ee3
Source noteuspto-grants-2010_04