HRID644240

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21906315

未命名化合物

结构：CC(C)c1ccc(C(=O)O)c(OCC2CCCN(C(=O)OC(C)(C)C)C2)c1

HCID68532264

未命名化合物

结构：CC(C)c1ccc(C(=O)Nc2ccc(F)cc2C(=O)Nc2ccc(Cl)cn2)c(OCC2CCCNC2)c1.Cl

HCID68571122

未命名化合物

PRODUCTS

生成物

结构：CC(C)c1ccc(C(=O)Nc2ccc(F)cc2C(=O)Nc2ccc(Cl)cn2)c(OCC2CCCNC2)c1.Cl.Cl

HCID68572225

未命名化合物

PROCEDURE

实验过程

Using methods substantially equivalent to those described in example 60-I & J, 2-[4-isopropyl-2-(piperidin-3-yl-methoxy)benzoylamino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide hydrochloride (92 mg, 0.15 mmol, 14%) was prepared from 4-isopropyl-2-(N-tert-butoxycarbonylpiperidin-3-yl)methoxybenzoic acid and N-(5-chloropyridin-2-yl)-2-amino-5-fluorobenzamide after reverse phase HPLC purification.

WORKUP

后处理

customafter reverse phase HPLC purification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aec0412a1c234dad84c724310f307f2b
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07700628B2
来源说明: uspto-grants-2010_04

反应 SMILES

Cl.[CH:2]([C:5]1[CH:30]=[CH:29][C:8]([C:9]([NH:11][C:12]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:13]=2[C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][N:18]=2)=[O:15])=[O:10])=[C:7]([O:31][CH2:32][CH:33]2[CH2:38][CH2:37][CH2:36][NH:35][CH2:34]2)[CH:6]=1)([CH3:4])[CH3:3].C(C1C=CC(C(O)=O)=C(OCC2CCCN(C(OC(C)(C)C)=O)C2)C=1)(C)C.[Cl:66]C1C=CC(NC(=O)C2C=C(F)C=CC=2N)=NC=1>>[ClH:23].[ClH:66].[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([NH:16][C:14](=[O:15])[C:13]2[CH:24]=[C:25]([F:28])[CH:26]=[CH:27][C:12]=2[NH:11][C:9](=[O:10])[C:8]2[CH:29]=[CH:30][C:5]([CH:2]([CH3:4])[CH3:3])=[CH:6][C:7]=2[O:31][CH2:32][CH:33]2[CH2:38][CH2:37][CH2:36][NH:35][CH2:34]2)=[N:18][CH:19]=1