HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-amino-N-(5-chloropyridin-2-yl)-5-fluorobenzamide → N-(5-Chloropyridin-2-yl)-5-fluoro-2-[4-isopropyl-2-(piperidin-3-yl-methoxy)benzoylamino]benzamide Dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-amino-N-(5-chloropyridin-2-yl)-5-fluorobenzamide | HCID 21906315 | — |
| Reactant | 4-isopropyl-2-(N-tert-butoxycarbonylpiperidin-3-yl)methoxybenzoic acid | HCID 68532264 | — |
| Reactant | 2-[4-isopropyl-2-(piperidin-3-yl-methoxy)benzoylamino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide hydrochloride | HCID 68571122 | — |
| Product | N-(5-Chloropyridin-2-yl)-5-fluoro-2-[4-isopropyl-2-(piperidin-3-yl-methoxy)benzoylamino]benzamide Dihydrochloride | HCID 68572225 | — |
Reaction Steps
Using methods substantially equivalent to those described in example 60-I & J, 2-[4-isopropyl-2-(piperidin-3-yl-methoxy)benzoylamino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide hydrochloride (92 mg, 0.15 mmol, 14%) was prepared from 4-isopropyl-2-(N-tert-butoxycarbonylpiperidin-3-yl)methoxybenzoic acid and N-(5-chloropyridin-2-yl)-2-amino-5-fluorobenzamide after reverse phase HPLC purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-aec0412a1c234dad84c724310f307f2b |
| Source note | uspto-grants-2010_04 |