3-Amino-5-methylisoxazole → 5-Fluoro-N-(5-methylisoxazol-3-yl)-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide

HRID 644248Notes

Reaction equation

HRID 644248 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([N:17]4[CH2:21][CH2:20][CH2:19][CH2:18]4)=[CH:13][C:12]=3[O:22][CH:23]3[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]3)[O:8][C:7](=[O:30])[C:6]=2[CH:31]=1.[NH2:32][C:33]1[CH:37]=[C:36]([CH3:38])[O:35][N:34]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:10][C:9](=[O:8])[C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)=[CH:13][C:12]=2[O:22][CH:23]2[CH2:24][CH2:25][N:26]([CH3:29])[CH2:27][CH2:28]2)=[C:6]([CH:31]=1)[C:7]([NH:32][C:33]1[CH:37]=[C:36]([CH3:38])[O:35][N:34]=1)=[O:30]

Participants

3

Reactant 2

HCID 661723-Amino-5-methylisoxazoleHCID 578608426-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-one

Product 1

HCID 578607725-Fluoro-N-(5-methylisoxazol-3-yl)-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide

Procedure

Using methods substantially equivalent to those described in Example 91-G, 5-fluoro-N-(5-methylisoxazol-3-yl)-2-[2-(1-methylpiperidin-4-ylxy)-4-(pyrrlidin-1-yl)-benzoylamino]benzamide was prepared from 6-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-one and 3-amino-5-methylisoxazole.

Sources & evidence

ORD record
ord-3859aa078f8048a5aaef41f999c53b3b
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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