HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-5-methylisoxazole → 5-Fluoro-N-(5-methylisoxazol-3-yl)-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-5-methylisoxazole | HCID 66172 | — |
| Reactant | 6-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-one | HCID 57860842 | — |
| Product | 5-Fluoro-N-(5-methylisoxazol-3-yl)-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide | HCID 57860772 | — |
Reaction Steps
Using methods substantially equivalent to those described in Example 91-G, 5-fluoro-N-(5-methylisoxazol-3-yl)-2-[2-(1-methylpiperidin-4-ylxy)-4-(pyrrlidin-1-yl)-benzoylamino]benzamide was prepared from 6-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-one and 3-amino-5-methylisoxazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-3859aa078f8048a5aaef41f999c53b3b |
| Source note | uspto-grants-2010_04 |