HRID644251

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7257

3,4-Dichloroaniline

C6H5Cl2N

HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

结构：CN1CCC(Oc2cc(N3CCCC3)ccc2-c2nc3ccc(F)cc3c(=O)o2)CC1

HCID57860842

未命名化合物

PRODUCTS

生成物

结构：CN1CCC(Oc2cc(N3CCCC3)ccc2C(=O)Nc2ccc(F)cc2C(=O)Nc2ccc(Cl)c(Cl)c2)CC1

HCID57860836

未命名化合物

PROCEDURE

实验过程

Using methods substantially equivalent to those described in Example 91-G, except using potassium t-butoxide as the base; N-(3,4-dichlorophenyl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide was prepared from 6-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-one and 3,4-dichloroaniline.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-14e25b30935041caafa5f90a8c56b42e
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07700628B2
来源说明: uspto-grants-2010_04

反应 SMILES

CC(C)([O-])C.[K+].[F:7][C:8]1[CH:9]=[CH:10][C:11]2[N:16]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)=[CH:19][C:18]=3[O:28][CH:29]3[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]3)[O:14][C:13](=[O:36])[C:12]=2[CH:37]=1.[Cl:38][C:39]1[CH:40]=[C:41]([CH:43]=[CH:44][C:45]=1[Cl:46])[NH2:42]>>[Cl:38][C:39]1[CH:40]=[C:41]([NH:42][C:13](=[O:36])[C:12]2[CH:37]=[C:8]([F:7])[CH:9]=[CH:10][C:11]=2[NH:16][C:15](=[O:14])[C:17]2[CH:22]=[CH:21][C:20]([N:23]3[CH2:24][CH2:25][CH2:26][CH2:27]3)=[CH:19][C:18]=2[O:28][CH:29]2[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]2)[CH:43]=[CH:44][C:45]=1[Cl:46]