3,4-Dichloroaniline → N-(3,4-dichlorophenyl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide

Participants

Role	Name	HCID	Charge
Reactant	3,4-Dichloroaniline	HCID 7257	—
Reactant	Potassium tert-butoxide	HCID 23665647	—
Reactant	6-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-one	HCID 57860842	—
Product	N-(3,4-dichlorophenyl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide	HCID 57860836	—

Reaction Steps

Using methods substantially equivalent to those described in Example 91-G, except using potassium t-butoxide as the base; N-(3,4-dichlorophenyl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide was prepared from 6-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-one and 3,4-dichloroaniline.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07700628B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-14e25b30935041caafa5f90a8c56b42e
Source note	uspto-grants-2010_04