HRID644253

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID520721

1,3-Dimethyl-1H-pyrazol-5-amine

C5H9N3

结构：CN1CCC(Oc2cc(N3CCCC3)ccc2-c2nc3ccc(F)cc3c(=O)o2)CC1

HCID57860842

未命名化合物

结构：Cc1nn(C)cc1NC(=O)c1cc(F)ccc1NC(=O)c1ccc(N2CCCC2)cc1OC1CCN(C)CC1.Cl

HCID68534027

未命名化合物

PRODUCTS

生成物

结构：Cc1nn(C)cc1NC(=O)c1cc(F)ccc1NC(=O)c1ccc(N2CCCC2)cc1OC1CCN(C)CC1

HCID57860919

未命名化合物

PROCEDURE

实验过程

Using methods substantially equivalent to those described in Example 118, N-(1,3-dimethylpyrazol-4-yl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide hydrochloride was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 5-amino-1,3-dimethylpyrazole.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f4dda8d3dcdf4f3c87579a4a04d4646b
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07700628B2
来源说明: uspto-grants-2010_04

反应 SMILES

Cl.[CH3:2][N:3]1[CH:7]=[C:6]([NH:8][C:9](=[O:39])[C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[NH:17][C:18](=[O:38])[C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:21][C:20]=2[O:30][CH:31]2[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]2)[C:5]([CH3:40])=[N:4]1.FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.NC1N(C)N=C(C)C=1>>[CH3:2][N:3]1[CH:7]=[C:6]([NH:8][C:9](=[O:39])[C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[NH:17][C:18](=[O:38])[C:19]2[CH:24]=[CH:23][C:22]([N:25]3[CH2:26][CH2:27][CH2:28][CH2:29]3)=[CH:21][C:20]=2[O:30][CH:31]2[CH2:36][CH2:35][N:34]([CH3:37])[CH2:33][CH2:32]2)[C:5]([CH3:40])=[N:4]1