HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dimethyl-1H-pyrazol-5-amine → N-(1,3-Dimethylpyrazol-4-yl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dimethyl-1H-pyrazol-5-amine | HCID 520721 | — |
| Reactant | 6-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-one | HCID 57860842 | — |
| Reactant | N-(1,3-dimethylpyrazol-4-yl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide hydrochloride | HCID 68534027 | — |
| Product | N-(1,3-Dimethylpyrazol-4-yl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide | HCID 57860919 | — |
Reaction Steps
Using methods substantially equivalent to those described in Example 118, N-(1,3-dimethylpyrazol-4-yl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide hydrochloride was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 5-amino-1,3-dimethylpyrazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-f4dda8d3dcdf4f3c87579a4a04d4646b |
| Source note | uspto-grants-2010_04 |