2,4-Dimethylpyridine → HCID 57860872, compound

HRID 644259Notes

Reaction equation

HRID 644259 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C:9]1[CH:14]=[C:13]([CH3:15])[N:12]=[C:11]([NH:16][C:17](=[O:47])[C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[NH:25][C:26](=[O:46])[C:27]2[CH:32]=[CH:31][C:30]([N:33]3[CH2:37][CH2:36][CH2:35][CH2:34]3)=[CH:29][C:28]=2[O:38][CH:39]2[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]2)[CH:10]=1.FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.CC1C=C(C)N=CC=1>>[CH3:8][C:9]1[CH:14]=[C:13]([CH3:15])[N:12]=[C:11]([NH:16][C:17](=[O:47])[C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[NH:25][C:26](=[O:46])[C:27]2[CH:32]=[CH:31][C:30]([N:33]3[CH2:34][CH2:35][CH2:36][CH2:37]3)=[CH:29][C:28]=2[O:38][CH:39]2[CH2:40][CH2:41][N:42]([CH3:45])[CH2:43][CH2:44]2)[CH:10]=1

Participants

4

Reactant 3

HCID 79362,4-DimethylpyridineHCID 578608426-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-oneHCID 68534253HCID 68534253, compound

Product 1

HCID 57860872HCID 57860872, compound

Procedure

Using methods substantially equivalent to those described in Example 118, N-(4,6-dimethylpyridin-2-yl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide trifluoroacetate was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 4,6-dimethyl-pyridine.

Sources & evidence

ORD record
ord-cf57e21b577740819282d798dbe26f8f
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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