4-Bromo-2-chloroaniline → HCID 57860927, compound

HRID 644261Notes

Reaction equation

HRID 644261 reaction equation
FC(F)(F)C(O)=O.[Br:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:46])[C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[NH:24][C:25](=[O:45])[C:26]2[CH:31]=[CH:30][C:29]([N:32]3[CH2:36][CH2:35][CH2:34][CH2:33]3)=[CH:28][C:27]=2[O:37][CH:38]2[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]2)=[C:11]([Cl:47])[CH:10]=1.FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.BrC1C=CC(N)=C(Cl)C=1>>[Br:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:46])[C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[NH:24][C:25](=[O:45])[C:26]2[CH:31]=[CH:30][C:29]([N:32]3[CH2:36][CH2:35][CH2:34][CH2:33]3)=[CH:28][C:27]=2[O:37][CH:38]2[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]2)=[C:11]([Cl:47])[CH:10]=1

Participants

4

Reactant 3

HCID 6101694-Bromo-2-chloroanilineHCID 578608426-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-oneHCID 86634212HCID 86634212, compound

Product 1

HCID 57860927HCID 57860927, compound

Procedure

Using methods substantially equivalent to those described in Example 118, N-(4-bromo-2-chlorophenyl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide trifluoroacetate was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 4-bromo-2-chloroaniline.

Sources & evidence

ORD record
ord-c96d2344671040dea97bdfaa6ca8ec9e
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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