2-Methoxybenzaldehyde → HCID 68532651, compound

HRID 644273Notes

Reaction equation

HRID 644273 reaction equation
CO[C:3]1[CH:31]=[CH:30][C:6]([C:7]([NH:9][C:10]2[CH:26]=[C:25]([N+:27]([O-:29])=[O:28])[CH:24]=[CH:23][C:11]=2[C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[O:13])=[O:8])=[C:5]([O:32][CH:33]2[CH2:38][CH2:37][N:36]([CH2:39][C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=3[O:46][CH3:47])[CH2:35][CH2:34]2)[CH:4]=1.[CH3:48][O:49]C1C=CC(C(NC2C=C([N+]([O-])=O)C=CC=2C(NC2C=CC(OC)=CC=2)=O)=O)=C(OC2CCNCC2)C=1.COC1C=CC=CC=1C=O>>[CH3:48][O:49][C:33]1([O:32][C:5]2[CH:4]=[CH:3][CH:31]=[CH:30][C:6]=2[C:7]([NH:9][C:10]2[CH:26]=[C:25]([N+:27]([O-:29])=[O:28])[CH:24]=[CH:23][C:11]=2[C:12]([NH:14][C:15]2[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=2)=[O:13])=[O:8])[CH2:38][CH2:37][N:36]([CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=2[O:46][CH3:47])[CH2:35][CH2:34]1

Participants

4

Reactant 3

HCID 86582-MethoxybenzaldehydeHCID 57860778HCID 57860778, compoundHCID 57860851HCID 57860851, compound

Product 1

HCID 68532651HCID 68532651, compound

Procedure

Using methods substantially equivalent to those described in Example 94-E, 2-[4-methoxy-2-[1-(2-methoxybenzyl)piperidin-4-yloxy]benzoylamino]-N-(4-methoxy-phenyl)-4-nitrobenzamide (83 mg, 0.13 mmol, 86%) was prepared from 2-[4-methoxy-2-(piperidin-4-yloxy)benzoylamino]-N-(4-methoxyphenyl)-4-nitrobenzamide and 2-methoxybenzaldehyde.

Sources & evidence

ORD record
ord-8e318d81988e46cf913f138e0285e82f
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

Loading…