Hydrochloric Acid → HCID 57860793, compound

HRID 644294Notes

Reaction equation

HRID 644294 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:40]=[C:39]([O:41]COC)[CH:38]=[CH:37][C:16]=2[C:17]([NH:19][C:20]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][C:21]=2[C:22]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][N:26]=2)=[O:23])=[O:18])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>CO.O1CCOCC1>[Cl:31][C:28]1[CH:29]=[CH:30][C:25]([NH:24][C:22](=[O:23])[C:21]2[CH:32]=[C:33]([F:36])[CH:34]=[CH:35][C:20]=2[NH:19][C:17](=[O:18])[C:16]2[CH:37]=[CH:38][C:39]([OH:41])=[CH:40][C:15]=2[O:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:26][CH:27]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68533915HCID 68533915, compound

Product 1

HCID 57860793HCID 57860793, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

2-[2-(1-tert-Butoxycarbonylpiperidin-4-yloxy)-4-(methoxymethoxy)benzoyl-amino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide (6.70 g, 10.7 mmol) was suspended in methanol (18 mL). 4 N HCl in dioxane (35 mL) was added and the resulting solution stirred at room temperature under nitrogen for 2 h. The reaction was cooled to 0° C. and cautiously quenched with saturated aqueous sodium bicarbonate. The resulting precipitate was collected and dried in a vacuum oven to give a quantitative yield of the title product as a fine white powder.

Workup

  1. temperatureThe reaction was cooled to 0° C.
  2. customcautiously quenched with saturated aqueous sodium bicarbonate
  3. customThe resulting precipitate was collected
  4. customdried in a vacuum oven

Sources & evidence

ORD record
ord-9e1a57c674294270b297544b0d843f01
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

Loading…