1-(4-Piperidin-4-yl-piperazin-1-yl)-ethanone → 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-[(R)-2-[4-(4-acetyl-piperazin-1-yl)-piperidin-1-yl]-1-(3,4-diethyl-benzyl)-2-oxo-ethyl]-amide
Reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:11][C@@H:12]([NH:16][C:17]([N:19]2[CH2:24][CH2:23][CH:22]([N:25]3[CH2:31][CH2:30][C:29]4[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=4[NH:27][C:26]3=[O:36])[CH2:21][CH2:20]2)=[O:18])[C:13](O)=[O:14])[CH:6]=[CH:7][C:8]=1[CH2:9][CH3:10])[CH3:2].[NH:37]1[CH2:42][CH2:41][CH:40]([N:43]2[CH2:48][CH2:47][N:46]([C:49](=[O:51])[CH3:50])[CH2:45][CH2:44]2)[CH2:39][CH2:38]1>>[C:49]([N:46]1[CH2:45][CH2:44][N:43]([CH:40]2[CH2:39][CH2:38][N:37]([C:13](=[O:14])[C@H:12]([NH:16][C:17]([N:19]3[CH2:20][CH2:21][CH:22]([N:25]4[CH2:31][CH2:30][C:29]5[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=5[NH:27][C:26]4=[O:36])[CH2:23][CH2:24]3)=[O:18])[CH2:11][C:5]3[CH:6]=[CH:7][C:8]([CH2:9][CH3:10])=[C:3]([CH2:1][CH3:2])[CH:4]=3)[CH2:42][CH2:41]2)[CH2:48][CH2:47]1)(=[O:51])[CH3:50]Participants
3
Reactant 2
Product 1
Procedure
Prepared analogously to Example 9i) from 400 mg (0.81 mmol) (R)-3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid and 230 mg (1.09 mmol) 1-(4-piperidin-4-yl-piperazin-1-yl)-ethanone.
Sources & evidence
- ORD record
- ord-bc4b7c9460964985a2b4f94f77cbe49d
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07700589B2
Reaction notes
Loading…