1-(4-Piperidin-4-yl-piperazin-1-yl)-ethanone → 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-[(R)-2-[4-(4-acetyl-piperazin-1-yl)-piperidin-1-yl]-1-(3,4-diethyl-benzyl)-2-oxo-ethyl]-amide

Participants

Reaction Steps

Prepared analogously to Example 9i) from 400 mg (0.81 mmol) (R)-3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid and 230 mg (1.09 mmol) 1-(4-piperidin-4-yl-piperazin-1-yl)-ethanone.

Provenance & Evidence