反应详情

1.26 g (20.0 mmol) sodium cyanoborohydride was added batchwise at RT to a stirred mixture of 1.71 g (5.0 mmol) tert-butyl 4-piperazin-1-yl-piperidine-1-carboxylate dihydrochloride, 0.75 mL (10.0 mmol) cyclopropanecarbaldehyde, 30 mL EtOH and 20 mL MeOH and stirred overnight at RT. The reaction mixture was evaporated down under reduced pressure, the residue was taken up in saturated NaHCO3 solution and extracted erschöpfend with EtOAc. The combined organic phases were dried over Na2SO4, suction filtered, evaporated down under reduced pressure and purified by column chromatography over silica gel.

1. customThe reaction mixture was evaporated down under reduced pressure
2. extractionextracted erschöpfend with EtOAc
3. dry with materialThe combined organic phases were dried over Na2SO4, suction
4. filtrationfiltered
5. customevaporated down under reduced pressure
6. custompurified by column chromatography over silica gel