4,4-difluoro-1,4'-bipiperidine → HCID 10417127, compound

HRID 644331Notes

Reaction equation

HRID 644331 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:11][C@@H:12]([NH:16][C:17]([N:19]2[CH2:24][CH2:23][CH:22]([N:25]3[CH2:31][CH2:30][C:29]4[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=4[NH:27][C:26]3=[O:36])[CH2:21][CH2:20]2)=[O:18])[C:13]([OH:15])=O)[CH:6]=[CH:7][C:8]=1[CH2:9][CH3:10])[CH3:2].[F:37][C:38]1([F:50])[CH2:43][CH2:42][N:41]([CH:44]2[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]2)[CH2:40][CH2:39]1>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[CH2:9][CH3:10])[CH2:11][C@@H:12]([NH:16][C:17]([N:19]1[CH2:24][CH2:23][CH:22]([N:25]2[CH2:31][CH2:30][C:29]3[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=3[NH:27][C:26]2=[O:36])[CH2:21][CH2:20]1)=[O:18])[C:13]([N:47]1[CH2:48][CH2:49][CH:44]([N:41]2[CH2:40][CH2:39][C:38]([F:50])([F:37])[CH2:43][CH2:42]2)[CH2:45][CH2:46]1)=[O:15])[CH3:2]

Participants

3

Reactant 2

HCID 534187744,4-difluoro-1,4'-bipiperidineHCID 68579001(R)-3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid

Product 1

HCID 10417127HCID 10417127, compound

Procedure

Prepared analogously to Example 9i) from 400 mg (0.81 mmol) (R)-3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid and 200 mg (0.98 mmol) 4,4-difluoro-[1,4′]bipiperidinyl.

Sources & evidence

ORD record
ord-934ce007f9fa429c8046a0e448cd83b3
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

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