HuagongsheHuagongshe Chemistry Print Report · For research reference only
Monoethyl 2-acetylamino-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-malonate → Ethyl 2-acetylamino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Monoethyl 2-acetylamino-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-malonate | HCID 86615683 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 2-acetylamino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionate | HCID 68579182 | — |
Reaction Steps
A mixture of 29.2 g (87.6 mmol) monoethyl 2-acetylamino-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-malonate and 400 mL toluene was refluxed for 5 h. The reaction mixture was then washed with 1 M NaOH and water, dried and evaporated down under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700589B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-71312201df69436280f37298f8fee9ec |
| Source note | uspto-grants-2010_04 |