ethyl (R)-2-acetylamino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionate → (R)-2-amino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionic acid

Participants

Reaction Steps

A mixture of 10.0 g (34.6 mmol) ethyl (R)-2-acetylamino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionate and 120 mL 6 M HCl was refluxed for 3 h. The reaction mixture was cooled in the ice bath, the precipitate was suction filtered, washed with water and diisopropylether and dried.

Provenance & Evidence