ethyl (R)-2-acetylamino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionate → (R)-2-amino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionic acid

HRID 644335Notes

Reaction equation

HRID 644335 reaction equation
C([NH:4][C@H:5]([CH2:11][C:12]1[CH:21]=[CH:20][C:19]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=2[CH:13]=1)[C:6]([O:8]CC)=[O:7])(=O)C>Cl>[NH2:4][C@H:5]([CH2:11][C:12]1[CH:21]=[CH:20][C:19]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=2[CH:13]=1)[C:6]([OH:8])=[O:7]

Participants

3

Reactant 1

HCID 69719715ethyl (R)-2-acetylamino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionate

Product 1

HCID 68578864(R)-2-amino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 10.0 g (34.6 mmol) ethyl (R)-2-acetylamino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionate and 120 mL 6 M HCl was refluxed for 3 h. The reaction mixture was cooled in the ice bath, the precipitate was suction filtered, washed with water and diisopropylether and dried.

Workup

  1. temperaturewas refluxed for 3 h
  2. filtrationfiltered
  3. washwashed with water and diisopropylether
  4. customdried

Sources & evidence

ORD record
ord-13d9d2f9306a4daab9a43a8f3611fb4d
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

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