反应详情

A mixture of 15 mL THF, 0.830 g (3.4 mmol) ethyl (R)-2-amino-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionate and 0.63 g (3.8 mmol) CDT was stirred for 1 h in the ice bath and for 1 h at RT. Then 0.83 g (3.4 mmol) 5-phenyl-2-piperidin-4-yl-2,4-dihydro-[1,2,4]triazol-3-one was added and the mixture was refluxed for 3 h. The reaction mixture was evaporated down under reduced pressure, the residue was combined with 15% K2CO3 solution, the precipitate was suction filtered and dried.

1. temperaturethe mixture was refluxed for 3 h
2. customThe reaction mixture was evaporated down under reduced pressure
3. filtrationfiltered
4. customdried