HCID 23153399, compound → 4-(Azetidin-1-YL)piperidine

HRID 644356Notes

Reaction equation

HRID 644356 reaction equation
[N:1]1([CH:5]2[CH2:10][CH2:9][N:8](CC3C=CC=CC=3)[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[H][H]>CO.[Pd]>[N:1]1([CH:5]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 23153399HCID 23153399, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 231531094-(Azetidin-1-YL)piperidine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3.2 g (13.9 mmol) 4-azetidin-1-yl-1-benzyl-piperidine dissolved in 50 mL MeOH were hydrogenated in the autoclave in the presence of 0.5 g Pd/C (10%) at 50° C. and 3 bar hydrogen pressure until the calculated volume of hydrogen had been taken up. The catalyst was filtered off and the solvent was eliminated under reduced pressure.

Workup

  1. filtrationThe catalyst was filtered off

Sources & evidence

ORD record
ord-a920274d7d824753a91b7afa7bd1fc4f
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

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