1-Methyl-4,4'-bipiperidine → 1-(1'-methyl-[4,4']bipiperidinyl-1-yl)-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-butan-1,4-dione

Participants

Role	Name	HCID	Charge
Reactant	1-Methyl-4,4'-bipiperidine	HCID 7183041	—
Reactant	4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-butanoic acid	HCID 68579103	—
Product	1-(1'-methyl-[4,4']bipiperidinyl-1-yl)-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-butan-1,4-dione	HCID 59260984	—

Reaction Steps

Prepared analogously to Example 76e) from 4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-butanoic acid and 1-methyl-[4,4′]bipiperidinyl.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07700589B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-d77d506d06cf41e2a269bd2b87a3ac28
Source note	uspto-grants-2010_04