Hydrochloric Acid → 2-Methoxy-5-sulfamoylbenzoic acid

HRID 644426Notes

Reaction equation

HRID 644426 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Na+].Cl>CO>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13](=[O:16])(=[O:15])[NH2:14])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 118390Methyl 5-sulfamoyl-o-anisate

Product 1

HCID 896012-Methoxy-5-sulfamoylbenzoic acidYield 98.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 2-methoxy-5-sulfamoylbenzoate (4.91 g, 20 mmol) was dissolved in methanol (30 mL). 2N Aqueous sodium hydroxide (30 mL, 60 mmol) was added, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into 2N hydrochloric acid, and the separated solid was filtered to give the title compound (4.55 g, 98.3%) as a white solid.

Workup

  1. filtrationthe separated solid was filtered

Sources & evidence

ORD record
ord-5d5ae285f19041fe9cacd6c70b168902
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

Loading…