Thiourea → 2-amino-4-(tert-butyl)-1,3-thiazole-5-carbonitrile

HRID 644435Notes

Reaction equation

Br[CH:2]([C:5](=O)[C:6]([CH3:9])([CH3:8])[CH3:7])[C:3]#[N:4].[NH2:11][C:12]([NH2:14])=[S:13]>>[NH2:14][C:12]1[S:13][C:2]([C:3]#[N:4])=[C:5]([C:6]([CH3:9])([CH3:8])[CH3:7])[N:11]=1

Participants

Reactant 2

HCID 2723790Thiourea

HCID 11586483Bromo-pivaloylacetonitrile

Product 1

HCID 27685182-amino-4-(tert-butyl)-1,3-thiazole-5-carbonitrileYield 66.3%

Procedure

Using α-bromo-pivaloylacetonitrile and thiourea as the raw materials, the same operation as the Example 181(1) gave the title compound.

Sources & evidence

ORD record: ord-4c6199ff78b24ddc8b4a140d16772ad2
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07700655B2

Reaction notes

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