Hydrochloric Acid → 5-Bromo-N-{4-[(1,1-dimethyl)ethyl]-5-piperidinothiazol-2-yl)-2-hydroxybenzamide
Reaction equation
C([O:4][C:5]1[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][C:6]=1[C:7]([NH:9][C:10]1[S:11][C:12]([N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[C:13]([C:15]([CH3:18])([CH3:17])[CH3:16])[N:14]=1)=[O:8])(=O)C.[OH-].[Na+].Cl>C(O)C>[Br:29][C:26]1[CH:27]=[CH:28][C:5]([OH:4])=[C:6]([CH:25]=1)[C:7]([NH:9][C:10]1[S:11][C:12]([N:19]2[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]2)=[C:13]([C:15]([CH3:17])([CH3:18])[CH3:16])[N:14]=1)=[O:8]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Acetoxy-5-bromo-N-{4-[(1,1-dimethyl)ethyl]-5-piperidinothiazol-2-yl}-benzamide (crude product, 84.3 mg) was dissolved in ethanol (3 mL). 2N Aqueous sodium hydroxide (0.1 mL) was added, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into 2N hydrochloric acid and extracted with ethyl acetate. After the organic layer was washed with water and brine, dried over anhydrous sodium sulfate, the residue obtained by evaporation under reduced pressure was purified by chromatography on silica gel (n-hexane:ethyl acetate=4:1) to give the title compound (54.1 mg, 36.3%; 2 steps) as a white powder.
Workup
- extractionextracted with ethyl acetate
- washAfter the organic layer was washed with water and brine
- dry with materialdried over anhydrous sodium sulfate
- customthe residue obtained by evaporation under reduced pressure
- customwas purified by chromatography on silica gel (n-hexane:ethyl acetate=4:1)
Sources & evidence
- ORD record
- ord-5ee890246f8042a3acf8d9e87b49d9d5
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07700655B2
Reaction notes
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