Benzenamine, 3,5-bis(trifluoromethyl)- → 4-Bromo-3-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]thiophene-2-carboxamide

HRID 644465Notes

Reaction equation

HRID 644465 reaction equation
[Br:1][C:2]1[C:3]([OH:10])=[C:4]([C:7]([OH:9])=O)[S:5][CH:6]=1.[F:11][C:12]([F:25])([F:24])[C:13]1[CH:14]=[C:15]([CH:17]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:19]=1)[NH2:16]>>[Br:1][C:2]1[C:3]([OH:10])=[C:4]([C:7]([NH:16][C:15]2[CH:17]=[C:18]([C:20]([F:21])([F:22])[F:23])[CH:19]=[C:13]([C:12]([F:11])([F:24])[F:25])[CH:14]=2)=[O:9])[S:5][CH:6]=1

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 546892204-Bromo-3-hydroxythiophene-2-carboxylic acid

Product 1

HCID 546892194-Bromo-3-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]thiophene-2-carboxamideYield 82.4%

Procedure

Using 4-bromo-3-hydroxythiophene-2-carboxylic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the Example 16 gave the title compound.

Sources & evidence

ORD record
ord-76ccdd28ee8947ca981c4d69dd3b67eb
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

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