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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 644465Generated: October 30, 2026

Benzenamine, 3,5-bis(trifluoromethyl)- → 4-Bromo-3-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]thiophene-2-carboxamide

https://huagongshe.com/reaction/644465

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzenamine, 3,5-bis(trifluoromethyl)-HCID 9480—
Reactant4-Bromo-3-hydroxythiophene-2-carboxylic acidHCID 54689220—
Product4-Bromo-3-hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]thiophene-2-carboxamideHCID 5468921982.4%

Reaction Steps

Using 4-bromo-3-hydroxythiophene-2-carboxylic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the Example 16 gave the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07700655B2
Source datasetuspto-grants-2010_04
ORD IDord-76ccdd28ee8947ca981c4d69dd3b67eb
Source noteuspto-grants-2010_04