1,1,1-Trifluoro-5,5-dimethyl-2,4-hexanedione → 5-(tert-Butyl)-1-(4-nitrophenyl)-3-(trifluoromethyl)pyrazole

HRID 644475Notes

Reaction equation

HRID 644475 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3](=O)[CH2:4][C:5](=O)[C:6]([CH3:9])([CH3:8])[CH3:7].Cl.[N+:15]([C:18]1[CH:23]=[CH:22][C:21]([NH:24][NH2:25])=[CH:20][CH:19]=1)([O-:17])=[O:16]>>[C:6]([C:5]1[N:24]([C:21]2[CH:22]=[CH:23][C:18]([N+:15]([O-:17])=[O:16])=[CH:19][CH:20]=2)[N:25]=[C:3]([C:2]([F:13])([F:12])[F:1])[CH:4]=1)([CH3:9])([CH3:8])[CH3:7]

Participants

3

Reactant 2

HCID 898301,1,1-Trifluoro-5,5-dimethyl-2,4-hexanedioneHCID 54634014-Nitrophenylhydrazine hydrochloride

Product 1

HCID 186771475-(tert-Butyl)-1-(4-nitrophenyl)-3-(trifluoromethyl)pyrazoleYield 94.7%

Procedure

Using 1,1,1-trifluoro-5,5-dimethyl-2,4-hexanedione and 4-nitrophenylhydrazine hydrochloride as the raw materials, the same operation as the Example 538(1) gave the title compound.

Sources & evidence

ORD record
ord-eba3089427ee4a3697ff0375ed43d87f
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

Loading…