1-(4-(Trifluoromethyl)phenyl)ethan-1-one → 4-[4-(Trifluoromethyl)phenyl]-1,3-thiazol-2-amine

HRID 644478Notes

Reaction equation

HRID 644478 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH3:10])=[CH:5][CH:4]=1.[NH2:14][C:15]([NH2:17])=[S:16]>>[NH2:17][C:15]1[S:16][CH:10]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:13])([F:12])[F:1])=[CH:4][CH:5]=2)[N:14]=1

Participants

3

Reactant 2

HCID 697311-(4-(Trifluoromethyl)phenyl)ethan-1-oneHCID 2723790Thiourea

Product 1

HCID 27377414-[4-(Trifluoromethyl)phenyl]-1,3-thiazol-2-amineYield 77.5%

Procedure

Using 4′-(trifluoromethyl)acetophenone and thiourea as the raw materials, the same operation as the Example 395(1) gave the title compound.

Sources & evidence

ORD record
ord-3f0e646ad3894f0e8ba95cded9d4b5ee
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

Loading…