3'-(Trifluoromethyl)acetophenone → 4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine

HRID 644495Notes

Reaction equation

HRID 644495 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([C:9](=O)[CH3:10])[CH:6]=[CH:7][CH:8]=1.[NH2:14][C:15]([NH2:17])=[S:16]>>[NH2:17][C:15]1[S:16][CH:10]=[C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:13])([F:12])[F:1])[CH:4]=2)[N:14]=1

Participants

3

Reactant 2

HCID 676823'-(Trifluoromethyl)acetophenoneHCID 2723790Thiourea

Product 1

HCID 7064574-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amineYield 94.1%

Procedure

Using 3′-(trifluoromethyl)acetophenone and thiourea as the raw materials, the same operation as the Example 395(1) gave the title compound.

Sources & evidence

ORD record
ord-67f4dfcfbc8a405ea17ff3319acd241c
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

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