反应详情

5-Cyano-7-(4-hydroxymethylphenyl)-1-phenylbenzimidazole was prepared from 5-cyano-7-iodo-1-phenylbenzimidazole (1.0 g, 2.90 mmol), 4-hydroxymethylphenylboronic acid (440 mg, 2.90 mmol), tetrakis(triphenylphosphine)palladium(0) (330 mg, 2.90 mmol) and potassium carbonate (2M in water, 2.9 ml, 800 mg, 5.8 mmol) in toluene (8.0 ml) and ethanol (2.0 ml) using the method described for 5-cyano-7-(3-hydroxymethylphenyl)-1-phenylbenzimidazole. 5-Cyano-7-(4-hydroxymethylphenyl)-1-phenylbenzimidazole was obtained as a white solid (711 mg) m/z, 326.3 (M+H)+.