反应详情

5-Cyano-7-(4-methanesulphonylmethylphenyl)-1-phenylbenzimidazole was prepared from 5-cyano-7-(4-hydroxymethylphenyl)-1-phenylbenzimidazole (500 mg, 1.54 mmol), diisopropylethylamine (0.82 ml, 4.62 mmol) and methanesulphonyl chloride (0.13 ml, 1.69 mmol) in dichloromethane (10 ml) using the method described for 5-cyano-7-(3-methanesulphonylmethylphenyl)-1-phenylbenzimidazole. The crude solution (approximately 0.14 M of product) was used directly in the next stage.